Products Of Vysali Pharmaceuticals

Ampicillin Sodium

SODAMPEN

1g & 500 mg
Powder for injection (iv/im)

FORMULATION

Each vial contains Ampicillin (as As sodium) 1g.

MECHANISM OF ACTION

Ampicillin sodium is a semi synthetic penicillin with an
extended spectrum of antimicrobial activity against most of the Gram ^+ve organism
as well as many Gram ^–ve bacilli. Ampicillin may also be less
susceptible to inactivation by some of the b
lactamase produced by these organisms. Ampicillin is effective against Non-penicillinase
producing Gram ^–ve organisms, Ampicillin is active against most of
the bacteria sensitive to Pencillin-G; but in addition it is active against some
Gram ^–ve bacilli,which are penicillin resistant. Ampicillin has
thus been referred to as a broad spectrum penicillin.

INDICATIONS

Ø
Ampicillin is effectively used in

Ø
Urinary tract Infection

Ø
Typhoid fever and other salmonalla infection

Ø
Respiratory tract infection

Ø
Bacterial meningitis

Ø
Billiary infection

Ø
Other surgical infection

Ø
Venereal disease

Ø
Brucellosis

CONTRAINDICATIONS

Ampicillin is contraindicated in patients known to be
sensitive to Penicillins and it should be used with caution in patients with
known history of allergy.

ADVERSE DRUG REACTIONS

Ampicillin may be cross allergic with oher penicillins, and
in sensitized patients it may evoke any hypersensitivity reactions. Skin rashes
are the most common side effect and are either urticarial or maculopapular.
Ampicillin therapy can cause gastro-intestinal side effect such as nausea and
diarrhoea, but these are not usually serious. These symptoms are usually seen in
children. In adults , diarrhoea may occur in 5-20% of
treated patients and is more common in older age groups. Blood disorders
such as thrombocytopenia occurs in some patients due to Ampicillin therapy.

STORAGE

Ampicillin injection should be stored in a temperature not
exceeding 30^oC.

CAUTION

Foods, drugs, devices and cosmetic act prohibits dispensing
without prescription

Benzylpenicilin

CRYSTACIN

1,000,000 I.U.
powder for injection (im\iv)

FORMULATION

Each vial contains benzylpenicilin (as sodium)
1,000,000I.U.

MECHANISM OF ACTION

It is an narrow spectrum, bactisidal antibiotic having a
rapid on set of action and
maintains effective bactisidal concentration
for 6hr. penicillins act by inhibiting the bacterial cellwall synthesis.

INDICATIONS

Benzylpencillin injection is indicated in the following
cases :

Ø
Bacterial endocarditis

Ø
Skin infection

Ø
Actinomycosis

Ø
Gonococcal arthritis

Ø
Endocarditis

Ø
Anthrax

Ø
Meningitis

Ø
Dental prophylaxis

Ø
Rheumatic fever

Ø
Urinary tract infection

Ø
Gonorrhoea

CONTRAINDICATIONS

It is contraindicated in patients with history of hyper
sensitivity to penicillin. Skin rashes of all types contact dermatitis, fever,
acute glossitis, serum sickness, angioedema, eosinophilia, anaphylaxis and
Arthus phenomenon may occur in allergic individuals. No toxic effect reported.

PRECAUTIONS

1.
Sensitivity test should be carried out before administration of
penicillin

2.
While using it along with aminoglycoside antibiotic it should not be
mixed with them.

3.
care is necessary while using sodium salts of penicillin in patients with
impaired renal function and congestive cardiac failure.

ADVERSE DRUG REACTIONS

STORAGE

Injection should be stored in temperature not exceeding 30^oC

CAUTION

Gentamicin sulfate

GENTROBEX

40mg /ml solution
for injection i.m / i.v

FORMULATION

Each vial contains Gentamicin sulfate 40mg.

MECHANISM OF ACTION

Gentamicin sulfate is a broad spectrum antibiotic which is
effective against a wide range of Gram ^+ve and Gram^-ve
bacteria. It is an ideal choice of treatment in infection of resistant strains
of pseudomonas aerogenosa. It is a bactericidal and acts by interfering with the
synthesis of bacterial proteins.

The principal use of gentamicin is for treatment of sever
systemic and urinary infections caused by organisms insensitive to the other
less toxic antibiotics.

INDICATIONS

Ø
Septicaemia and other sever infections due to aerobic Gram-^ve
bacilli.

Ø
Urinary tract infections

Ø
Staphylococcal infections

Ø
Bacterial endocarditis

Ø
Gastroeteritis

Ø
Chemoprophylaxis in abdominal surgery

Ø
Biliary tract infections

ADVERSE DRUG REACTIONS

Renal damage, partial or total deafness and vestibular
dysfunction have been reported following parenteral administrations of
Gentamicin for a few days. The severity and persistence of the symptoms normally
disappearing when the drug is withdrawn, the ototoxicity is irreversible
provided the recommended doses are not exceeded, Nephrotoxic and ototoxic
symptoms are unlikely to appear in patients with normal renal functions.

Warning

Contains: Sodium metabisulphite, a sulfite that may cause
allergic type reaction including anaphylactic symptoms and life threatening or
less sever asthatic episodes in certain susceptible individuals.

STORAGE

Store at temperature not exceeding 30^oC.

CAUTION